New numbers show one in 59 children live with Autism.
Now, the largest study of its kind is in search of breakthrough treatments to help families thrive.
Kiernan,5, and Skyler,12, are confirmed to have autism, while their brother Malachai, 6, is in the process of being diagnosed and is likely also on the spectrum.
Most people with autism spectrum disorder have social, communication, and other challenges.
"It's kind of a bombshell. You know, it blindsides you the first time you hear that," said mother Kami Denison. "It's, what did I do wrong?"
"You always wonder why something like that happens to you," said father Lance Denison.
They are common questions, but most scientists agree, autism isn’t something someone did.
The biggest risk factor is in their genes.
They hope to learn more through the largest genetic study of autism ever.
It's called SPARK - and researchers are recruiting 50,000 families across the country.
Families simply register online, receive a saliva collection kit in the mail and then use it submit their DNA.
"We're setting the stage for being able to answer these questions of why, and then how do we target treatment, how do we tailor a specific type of intervention to people that have this type of genetic change," said Dr. Jennifer Gertds, SPARKS project investigator.
The Denison family is part of the SPARK study.
They already know, each of the boys is unique.
Keirnan is non-verbal but compassionate.
Malachai is curious and energetic.
"I'm kind. And honest," said Skyler. "And, loyalty."
The boys likely have different genetic markers, putting them in different places on the autism spectrum.
Researchers want to know more about those differences.
"We wanted to be part of something that would help people in the future," said Kami. "When we found out about our boys, there's no manual that comes with that. You have to find the information."
"It seems to carry a lot of promise," said Lance. "And whatever comes of it, whether it's a little or a lot, it's more than we could have done on our own."
The Denison family prominently displays their family pride.
And they're willing to share more about their family - down to their DNA - in the hope that science will discover new treatments for autism.
If you wouldl ike to participate in the SPARK study, you can learn more on their website.